Lung disease: People with this condition often develop emphysema, with
symptoms of a hacking cough, barrel-shaped chest, and difficulty breathing. If
you have this condition and smoke or are exposed to tobacco smoke, it
accelerates the appearance of emphysema symptoms and lung damage.
Liver disease: Alpha-1 antitrypsin deficiency also cause liver disease in some people with the condition, that include liver cancer, cirrhosis of the liver, an abnormally large liver (hepatomegaly), liver failure, and hepatitis. Liver damage from alpha-1 antitrypsin deficiency causes symptom of a swollen abdomen, swollen legs or feet, and jaundice.
Treatment of AATD depends upon the severity of symptoms. FDA approved drug for AATD is an orphan product called alpha-1-proteinase inhibitor (human), sold under the brand name "Prolastin."
I had promised myself I would leave my hands mud free, but after reading your tweet today which stated how; ‘soon we will learn who in the media who has class, and who hasn’t’, has pushed me to this. That tweet was breathtakingly hypocritical, even for you. At no stage have you acted in a way that’s even remotely classy, yet you believe that’s the standard by which everyone should behave towards you? General Kelly will do a fine job. I’ll even admit he will do a better job than me. But the way in which that transition has come about has been diabolical. And hurtful. I don’t expect a reply.