I started on 5mg, then 10mg the following week, then 15mg each week after. Until I visit the dermos again I don't know if the dose will change. I take it on a Friday in the morning, then 5mg folic acid every day except Fridays. Feel ok all day Friday and feel ok Saturday too. Feel like absolute rubbish on Sunday's, as if I have the flu coming. Ache all over and feel wiped out and have to have a little lye down half way through the day. It's really inconvenient! Monday is ok. I don't get any sickness feeling or any other major side effects that you read about on forums etc. (So far anyway, touch wood!) I read that people who have bad nausea it might be better on injections rather than tablets.