Description of steroid

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(-)-(1'R)-2-methyl-4-(2',2',3'- trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-al - possesses an unexpected odor in view of the prior knowledge regarding the odor properties of campholenic aldehyde derivatives. It develops a woody-sandalwood type odor note, slightly aldehydic, which is more reminiscent of the cedar-pine odor connotation than of the sandalwood type one, which note is combined with a distinct marine, ozone character. The latter is reinforced in the bottom note, which is strongly ozone-marine-like, recalling the odor of seaweeds. In addition, the odor of this compound has a good strength and tenacity.

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

Description of steroid

description of steroid


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