Chapter 12 terpenoids and steroids

Although cannabinoids get all the press, marijuana does contain over 100 terpenoids which are aromatic chemicals that can also be found in pine trees, citrus flora, and other odoriferous plants. Terpenoids produce the unique aroma and flavor of marijuana, but many researchers believe that terpenoids might have significant medicinal effects. In comparison to the cannabinoids, little is really known about terpenoids in cannabis. You’ll find more information about them in Chapter 5 (Growing Medical Marijuana) and Chapter 9 (Choosing a Variety).

Ivermectin  — This is the most recently developed treatment for scabies. It’s known as an effective oral alternative that has been useful in crusted scabies, patients who are bed-ridden and in institutional outbreaks. The single oral dose of ivermectin , 200 micrograms per kilogram of body weight, is a well-tolerated and very effective treatment. However, there are some side effects, including headaches, dizziness, muscle pain, nausea and diarrhea. Ivermectin is valued for its use as a simple treatment for close contacts who may not even show signs of scabies infestation. ( 16 )

While health authorities encourage consumers to eat diets rich in fruit, vegetables, whole grains , legumes , and nuts to improve and maintain health, [12] evidence that such effects result from specific, non-nutrient phytochemicals is limited or absent. [4] For example, systematic reviews and/or meta-analyses indicate weak or no evidence for phytochemicals from plant food consumption having an effect on breast , lung , or bladder cancers. [25] [26] Further, in the United States, regulations exist to limit the language on product labels for how plant food consumption may affect cancers, excluding mention of any phytochemical except for those with established health benefits against cancer, such as dietary fiber , vitamin A , and vitamin C . [27]


Revalidation after changes. Revalidation must be performed on introduction of any changes affecting a manufacturing and/or standard procedure having a bearing on the established product performance characteristics. Such changes may include those in starting material, packaging material, manufacturing processes, equipment, in-process controls, manufacturing areas, or support systems (water, steam, etc.). Every such change requested should be reviewed by a qualified validation group, which will decide whether it is significant enough to justify revalidation and, if so, its extent.

Chapter 12 terpenoids and steroids

chapter 12 terpenoids and steroids


Revalidation after changes. Revalidation must be performed on introduction of any changes affecting a manufacturing and/or standard procedure having a bearing on the established product performance characteristics. Such changes may include those in starting material, packaging material, manufacturing processes, equipment, in-process controls, manufacturing areas, or support systems (water, steam, etc.). Every such change requested should be reviewed by a qualified validation group, which will decide whether it is significant enough to justify revalidation and, if so, its extent.

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